Bioinformatician (Genomic Profiling) Position at Pfizer

[Daz]

Quote:Bioinformatician: Genomic Profiling

An exciting opportunity has arisen within the new Pfizer Regenerative Medicine unit in Cambridge, UK for a skilled computational scientist to assist in the analysis and interpretation of large-scale molecular profiling data. Our goal is to understand the molecular events concerning stem-cell differentiation and identify novel mechanisms to promote the generation of specific cell types. As part of this work we will be performing extensive molecular profiling studies and are seeking a computational biologist with experience in this area. The successful candidate will be working on a diverse range of projects investigating the pathways controlling the generation of therapeutically-relevant cell types and the identification of potential therapeutic targets.

We are specifically interested in anyone candidates with knowledge of techniques such as micro-RNA, microarray, ChIP-ChIP, ChIP-Seq, next generation sequencing and epigenetic profiling analyses. The ideal candidate would be able to demonstrate previous experience in processing and downstream analysis of such data, ideally using multiple different datasets. The candidate will also need to demonstrate an understanding of good experimental design, considering the issues with regards to replicates, time-studies and use of appropriate controls. A solid background in statistical analysis of molecular profiling is essential and candidates should be proficient in the use of systems such as R/Bioconductor. Awareness of the issues and practical steps concerning integration of multiple datasets would also be desirable, as would previous use of integration and analysis tools. An ability to communicate findings to group is essential, as is an interest in the biological application of such data such as pathway and systems analysis.

Pfizer Regenerative Medicine is a new research unit working at the forefront of science using the latest developments in stem cell biology to bring novel treatments straight to patients to prevent disability, repair failing organs, treat degenerative diseases and even slow down parts of the ageing process. We work within the Guidelines developed by the National Academy of Sciences in the USA and equivalent organisations around the world. Pfizer Regenerative Medicine, has been set up as an entrepreneurial business unit in the UK and US to focus on delivering a new generation of innovative medicinal products. For us, this is the start of a new era of medicine – and Pfizer Regenerative Medicine will not only be part of it, but shape it.

Key Skills: Molecular Profiling/’omics/high-throughput technologies; Microarray/Epigenetics/Next generation sequencing; bioinformatics; computational biology; statistical analysis; R/Bioconductor; Ensembl; GO/GSEA; Solexa/Illumina/Affymetrix/454.


To find out more and to apply visit http://www.pfizer.co.uk/careers and enter the job opening I.D. 929568

Closing date: 26th February 2009.

We’re proud to be an equal opportunity employer and welcome applications from people with different experiences, backgrounds and ethnic origins.